解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::Glioma is the most aggressive primary brain tumor. We have previously provided evidence that IFITM3 promoted glioma cells migration. However, the mechanism of how IFITM3 regulates glioma cells invasion and whether IFITM3 participates in TGF-β-mediated glioma invasion are still unknown. In this paper, we proved that IF...
journal_title:Molecular biology reports
pub_type: 杂志文章
doi:10.1007/s11033-019-05146-2
更新日期:2020-01-01 00:00:00
abstract::Serotonin receptor (5-HT) is a biogenic amine acting as a neurotransmitter and neuromodulator that mediates various aspects of reproduction and gametogenesis. The full-length nucleotide sequence of Haliotis discus hannai encodes a protein of 417 amino acids with a predicted molecular mass of 46.54 kDa and isoelectric ...
journal_title:Molecular biology reports
pub_type: 杂志文章
doi:10.1007/s11033-019-05162-2
更新日期:2020-01-01 00:00:00
abstract::BACs-on-Beads (BoBs™) assay is a rapid aneuploidy test (RAT) that detects numerical chromosomal aneuploidies and multiple microdeletion/microduplication syndromes. This study was conducted to appraise the usefulness of the BoB™ assay as a complementary diagnostic tool to conventional karyotyping for the rapid detectio...
journal_title:Molecular biology reports
pub_type: 杂志文章
doi:10.1007/s11033-019-05117-7
更新日期:2020-01-01 00:00:00
abstract::Circular RNA (circRNA), a novel type of non-coding RNA that consists of a circular loop, has been demonstrated to act as a "sponge" for microRNAs (miRNAs). However, the role of circRNAs in keloid remains unknown. In this study, we investigated circRNA expression profiles in keloid to identify potential diagnostic and ...
journal_title:Molecular biology reports
pub_type: 杂志文章
doi:10.1007/s11033-019-05120-y
更新日期:2020-01-01 00:00:00
abstract::Rice bran oil is good quality edible oil, rich in antioxidants and comprised typically of oleic-linoleic type fatty acids. However, presence of a highly lipolytic enzyme Phospholipase D alpha1 (OsPLDα1) increases free fatty acid content in the oil which further leads to stale flavor and rancidity of the oil, making it...
journal_title:Molecular biology reports
pub_type: 杂志文章
doi:10.1007/s11033-019-05144-4
更新日期:2020-01-01 00:00:00
abstract::The transforming growth factor-β (TGF-β) signaling pathway is conserved across animals, and knowledge of its roles during the molt cycle in crustaceans is presently very limited. This study investigates the roles of the TGF-β receptor in molting-related muscle growth in Eriocheir sinensis. Using the RT-PCR and RACE te...
journal_title:Molecular biology reports
pub_type: 杂志文章
doi:10.1007/s11033-019-05108-8
更新日期:2020-01-01 00:00:00
abstract::The disturbed immune homeostasis is involved in the pathogenesis of an array of autoimmune diseases like rheumatoid arthritis (RA). The adenosine monophosphate-activated protein kinase (AMPK) with a pivotal role in immunometabolism process, also plays a regulatory function in the immune system. This study aims to eval...
journal_title:Molecular biology reports
pub_type: 杂志文章
doi:10.1007/s11033-019-05078-x
更新日期:2019-12-01 00:00:00
abstract::1-Deoxynojirimycin (DNJ), the main alkaloid in mulberry leaves, was recognized to treat patients with type 2 diabetes mellitus (T2DM). However, the regulatory mechanism of DNJ on glucose homeostasis was still unclear. In the present study, a safe concentration of 0.1-10 μmol/L for DNJ was incubated with mature 3T3-L1 ...
journal_title:Molecular biology reports
pub_type: 杂志文章
doi:10.1007/s11033-019-05069-y
更新日期:2019-12-01 00:00:00
abstract::The novel dipstick DNA extraction method was tested for its reliability and usability for biological barcoding in comparison to a commercial kit and to a simplified isopropanol precipitation method using crayfish gill tissue. Following DNA extraction, the mitochondrial COI-gene was amplified in a PCR-reaction using a ...
journal_title:Molecular biology reports
pub_type: 杂志文章
doi:10.1007/s11033-019-05083-0
更新日期:2019-12-01 00:00:00
abstract::The differentially expressed genes in the chickpea pod wall have been identified for the first time using a forward suppression subtractive hybridization (SSH) library. In all, 226 clones of SSH library were sequenced and analyzed. A total of 179 high-quality expressed sequence tags (ESTs) were generated and based on ...
journal_title:Molecular biology reports
pub_type: 杂志文章
doi:10.1007/s11033-019-05005-0
更新日期:2019-12-01 00:00:00
abstract::Several mechanisms are involved in the loss of cellular integrity and tissue destructions in various brain regions during ischemic insult. The affected brain employs various self-repair mechanisms during the poststroke recovery. Therefore, the current study involves time course changes in different brain regions follo...
journal_title:Molecular biology reports
pub_type: 杂志文章
doi:10.1007/s11033-019-05060-7
更新日期:2019-12-01 00:00:00
abstract::Abnormally protein aggregation and deposition are key pathological features of ALS, which may related with dysfunctional cellular autophagy. In the current study, we found that, compared with wtSOD1 cells, serum starvation treatment resulted in significant higher percentage of apoptosis in mutSOD1 cells; Lithium treat...
journal_title:Molecular biology reports
pub_type: 杂志文章
doi:10.1007/s11033-019-05071-4
更新日期:2019-12-01 00:00:00
abstract::The immunity and health status of ornamental fish is an important aspect, as they are kept in a confined environment and various stressful conditions which lead to depletion of overall colourful appearance and mortality. The carotenoids can act as immunity boosters in captive aquarium system and may be supplemented in...
journal_title:Molecular biology reports
pub_type: 杂志文章
doi:10.1007/s11033-019-05027-8
更新日期:2019-12-01 00:00:00
abstract::Circulating long noncoding RNAs as biomarkers of diseases have attracted increasing attention recently. However, circulating lncRNAs in hypertension is still unexplored niche. The levels of lncRNAs GAS5, NR024118, MRAK134679, AX765700 and MRNR026574 were measured in the serum and myocardium of hypertensive rats and no...
journal_title:Molecular biology reports
pub_type: 杂志文章
doi:10.1007/s11033-019-05086-x
更新日期:2019-12-01 00:00:00
abstract::Overexpression of ATP-binding cassette (ABC) transporters causing multidrug resistance (MDR) in cancer cells is one of the major obstacles in cancer chemotherapy. The 5-FU resistant subclone (HL-60/5FU) of the human HL-60 promyelocytic leukemia cell line was selected by the conventional method of continuous exposure o...
journal_title:Molecular biology reports
pub_type: 杂志文章
doi:10.1007/s11033-019-05017-w
更新日期:2019-12-01 00:00:00
abstract::Rhodoleia Champion ex Hooker is one of the most primitive relict genera of Hamamelidaceae, a key family exploited to understand the origin and early evolution of flowering plants. Genomic simple sequence repeats (SSRs) were developed for R. championii to perform genetic diversity, phylogeographical structure or even s...
journal_title:Molecular biology reports
pub_type: 杂志文章
doi:10.1007/s11033-019-05106-w
更新日期:2019-12-01 00:00:00
abstract::Single nucleotide polymorphisms (SNPs) in adiponectin gene [rs1501299 (+276G/T) and rs266729 (-11377C/G)] and one SNP of leptin gene [rs7799039 (-2548G/A)] are known to influence plasma levels of adiponectin and leptin respectively. Literature is scarce on the association of adiponectin gene polymorphism rs266729 with...
journal_title:Molecular biology reports
pub_type: 杂志文章
doi:10.1007/s11033-019-05070-5
更新日期:2019-12-01 00:00:00
abstract::Plumbagin (PLB) is a phytochemical being used for centuries in traditional medicines. Recently, its capacity to inhibit the development of human tumors has been observed, through the induction of apoptosis, cell cycle arrest, and inhibition of angiogenesis and metastasis. Here we evaluated the mechanism of action of P...
journal_title:Molecular biology reports
pub_type: 杂志文章
doi:10.1007/s11033-019-05042-9
更新日期:2019-12-01 00:00:00
abstract::Gonadal dysgenesis (GD) is a rare cause of differences of sex development (DSD) with highly variable clinical and genetic conditions. Although identification of the causative genetic alterations can offer a clearer prognosis and personalized management to patients, more than 50% of the DSD cases still do not have an a...
journal_title:Molecular biology reports
pub_type: 杂志文章
doi:10.1007/s11033-019-04980-8
更新日期:2019-10-01 00:00:00
abstract::A reduction in the number of functional β-cells is the central pathological event in diabetes. Liver and ventral pancreas differentiates simultaneously in the same general domain of cells within embryonic endoderm. In addition, the precursor cell population being bi-potential may be targeted for either pancreas or liv...
journal_title:Molecular biology reports
pub_type: 杂志文章
doi:10.1007/s11033-019-04870-z
更新日期:2019-10-01 00:00:00
abstract::The investigation was carried out to analyse the genetic polymorphism and gene expression of ATP1A1 gene in four different Indian goat breeds by using high resolution melting (HRM) and real time-PCR. ATPase is electro-genic ion pump which is maintains the balance of sodium and potassium ions in animal cells. The trans...
journal_title:Molecular biology reports
pub_type: 杂志文章
doi:10.1007/s11033-019-04984-4
更新日期:2019-10-01 00:00:00
abstract::We have chosen to test the safety of human intracerebroventricular (ICV) brain injections of autologous non-genetically-modified adipose-derived stromal vascular fraction (ADSVF). In this IRB-approved trial, 24 patients received ICV ADSVF via an implanted reservoir between 5/22/14 and 5/22/17. Seven others were inject...
journal_title:Molecular biology reports
pub_type: 杂志文章
doi:10.1007/s11033-019-04983-5
更新日期:2019-10-01 00:00:00
abstract::One of the most crucial steps for preventing viral pandemics is the early detection of the causative virus on site. Various molecular and immunological approaches have been developed for virus detection. In this study, we investigated the utility of the recently introduced convection polymerase chain reaction (cPCR) p...
journal_title:Molecular biology reports
pub_type: 杂志文章
doi:10.1007/s11033-019-04961-x
更新日期:2019-10-01 00:00:00
abstract::Salvia lachnostachys is an herbaceous plant with anti-inflammatory, analgesic and cytotoxic properties. This study investigated the antitumor effect of an ethanolic extract of Salvia lachnostachys leaves (EES) in a solid Ehrlich carcinoma model. Ehrlich cells were inoculated subcutaneously in the right pelvic member (...
journal_title:Molecular biology reports
pub_type: 杂志文章
doi:10.1007/s11033-019-04931-3
更新日期:2019-10-01 00:00:00
abstract::Maintenance of glucose homeostasis is reciprocally regulated by insulin and glucagon-like peptide-1 (GLP-1). We previously reported that GLP-1 secretion in response to an oral glucose load was impaired following an administration of 3-deoxyglucosone (3DG), an independent factor associated with the development of pre-d...
journal_title:Molecular biology reports
pub_type: 杂志文章
doi:10.1007/s11033-019-04926-0
更新日期:2019-10-01 00:00:00
abstract::Type 2 diabetes is one of the most prevalent diseases, which increases resistance to insulin in target tissues. The measurement of miRNAs quantity is a molecular approach for diagnosis of diabetes. miRNAs are small non-coding RNA strings of 21-23 long nucleotides that act as inhibitors in proteins translation. Several...
journal_title:Molecular biology reports
pub_type: 杂志文章
doi:10.1007/s11033-019-04959-5
更新日期:2019-10-01 00:00:00
abstract::Growing data supported that epigenetic modifications, including altered DNA methylation have a potential role in the pathogenesis of autoimmune thyroid diseases (AITD). In the present study we aimed to investigate the methylation status of ICAM-1 gene promoter in patients with AITD. Forty patients with Graves' disease...
journal_title:Molecular biology reports
pub_type: 杂志文章
doi:10.1007/s11033-019-04990-6
更新日期:2019-10-01 00:00:00
abstract::The Editor-in-Chief has decided to retract this article [1]. The article shows significant overlap with two prior publications by the same authors [2, 3], without providing the due citation and attribution. ...
journal_title:Molecular biology reports
pub_type: 已发布勘误,撤回出版物
doi:10.1007/s11033-019-04760-4
更新日期:2019-10-01 00:00:00
abstract::Matrix metalloproteinases (MMPs) are implicated in atherosclerosis evolution into a coronary artery disease (CAD). They could be used as biomarkers for a predictive approach when they are studied simultaneously. We aim in our study to demonstrate prospectively in patients with history of CAD that MMPs level is linked ...
journal_title:Molecular biology reports
pub_type: 杂志文章
doi:10.1007/s11033-019-04914-4
更新日期:2019-10-01 00:00:00
abstract::Blood and liver from curimbata (Prochilodus lineatus) acclimated at pH 4.5, 7.0 and 8.0 and at 20 and 30 °C were exposed in vitro to different concentrations of copper (Cu): 98 ± 0.8 μg Cu L-1 at pH 4.5 and 16 ± 0.2 μg Cu L-1 at pH 8.0 at 20 °C; 88 ± 0.8 μg Cu L-1 at pH 4.5 and 14 ± 0.5 μg Cu L-1 at pH 8.0 at 30 °C an...
journal_title:Molecular biology reports
pub_type: 杂志文章
doi:10.1007/s11033-019-04944-y
更新日期:2019-10-01 00:00:00
abstract::Selenium compounds have been widely investigated as novel anticancer agents due to high efficacy and selectivity against cancer cells in recent years. This study aimed to research the potential inhibitory effects of seleno-β-lactoglobulin (Se-β-Lg) on HepG2 cells in vitro. MTT results demonstrated that the synthetized...
journal_title:Molecular biology reports
pub_type: 杂志文章
doi:10.1007/s11033-019-04953-x
更新日期:2019-10-01 00:00:00
abstract::Our previous study revealed that CRB3 protein expression was reduced in clear cell renal cell carcinoma (ccRCC) and was associated with TNM stage, pathological grade, and poor prognosis of ccRCC. This study aimed to investigate if DNA methylation of CRB3 decreases its expression, subsequently leading to the progressio...
journal_title:Molecular biology reports
pub_type: 杂志文章
doi:10.1007/s11033-019-04892-7
更新日期:2019-08-01 00:00:00
abstract::Colorectal cancer (CRC) is one of the most common cancers, and rates of incidence and diagnosis of CRC have gradually increased. Carcinoembryonic antigen (CEA) is overexpressed in patients with CRC and is associated with cell adhesion, anoikis resistance, and promotion of metastasis to the liver. 5-Fluorouracil (5-FU)...
journal_title:Molecular biology reports
pub_type: 杂志文章
doi:10.1007/s11033-019-04826-3
更新日期:2019-08-01 00:00:00
abstract::The purpose of our research is to elucidate whether oxLDL activates P2X7R in cultured human podocytes and if the activation of P2X7R leads to podocyte apoptosis. Additionally, we explore the underlying mechanism involved in podocyte apoptosis. Immortalized human podocytes were incubated with oxLDL (80 µg/ml), P2X7R an...
journal_title:Molecular biology reports
pub_type: 杂志文章
doi:10.1007/s11033-019-04823-6
更新日期:2019-08-01 00:00:00
abstract::α-Synuclein is a presynaptic neuronal protein that is abundant in the human brain and is linked genetically and neuropathologically to Parkinson's disease (PD). The E46K mutation of the α-synuclein gene has been linked to autosomal dominant early-onset of PD. Crocin is a carotenoid chemical compound of saffron that ha...
journal_title:Molecular biology reports
pub_type: 杂志文章
doi:10.1007/s11033-019-04882-9
更新日期:2019-08-01 00:00:00
abstract::Yangyin Tongnao granules (YYTNG) have been extensively applied in the treatment of brain injury, mainly due to its antioxidant effects, inhibition of apoptosis, and enhancement of blood circulation. To analyze the effect of YYTNG on the recovery of neurological function and neurogenesis in the peri-infarct area after ...
journal_title:Molecular biology reports
pub_type: 杂志文章
doi:10.1007/s11033-019-04824-5
更新日期:2019-08-01 00:00:00
abstract::Maize (Zea mays L.) is an important model plant with an important role in agriculture and national economies all over the world. The optimum growth temperature of maize is between 25 and 28 °C. At temperatures below 12 °C, maize is vulnerable to damage by chilling stress. MYB transcription factors play important roles...
journal_title:Molecular biology reports
pub_type: 杂志文章
doi:10.1007/s11033-019-04840-5
更新日期:2019-08-01 00:00:00
abstract::In this study we are presenting the development of technetium-99m (99mTc) labeled ibuprofen for the imaging of aseptic inflammation. 99mTc-Ibuprofen complex was developed by optimizing the radiolabeling conditions such as reaction time, ligand and reducing agent concentration, pH, reaction time and temperature. Follow...
journal_title:Molecular biology reports
pub_type: 杂志文章
doi:10.1007/s11033-019-04762-2
更新日期:2019-06-01 00:00:00
abstract::Brassica oleracea var. capitata (cabbage) is an economically important crop affected by black rot disease caused by Xanthomonas campestris pv. campestris (Xcc). MicroRNAs (miRNAs) play an important role in plant defense modulation and therefore the analysis of these molecules can help better understand plant-pathogen ...
journal_title:Molecular biology reports
pub_type: 杂志文章
doi:10.1007/s11033-019-04779-7
更新日期:2019-06-01 00:00:00
abstract::In the present study, Amukkara Chooram (AC) a well known herbal medicine was investigated for their antibiofilm efficacy against biofilm of Candida albicans. The biofilm inhibitory concentration of 20 µg/mL of AC showed promising effect by inhibiting the biofilm upto 60%. Morphogenic transition state of C. albicans fr...
journal_title:Molecular biology reports
pub_type: 杂志文章
doi:10.1007/s11033-019-04757-z
更新日期:2019-06-01 00:00:00